Computer systems and software play a vital role in the functioning of our society. Ensuring their security is of utmost importance and is more relevant now than ever before. Although various security measures have made it more challenging, adversaries keep finding innovative ways to exploit vulnerabilities around them. In this talk, I will share my vision for establishing trustworthy software and systems by showcasing examples of my work in the field. I will also address new security challenges at the intersection of software and microarchitectural vulnerabilities. Specifically, I will present our groundbreaking research on BlindSide, a new exploitation technique that relies on a single memory corruption vulnerability to hack the Linux kernel without causing any crashes. Finally, I will conclude by highlighting ongoing efforts and future research directions in the realm of systems and software security.